Free Access
| Issue |
Lait
Volume 62, Number 617-620, 1982
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|---|---|---|
| Page(s) | 409 - 414 | |
| DOI | https://doi.org/10.1051/lait:1982617-62026 | |
Lait 62 (1982) 409-414
DOI: 10.1051/lait:1982617-62026
Laboratoire de Chimie Biologique de l'Université des Sciences et Techniques de Lille / et Laboratoire associé au C.N.R.S. n° 217 - 59655 Villeneuve-d'Ascq
Key words: Immunoglobulins / Glycans / Human milk.
Mots clés : Immunoglobulines A / Glycannes / Lait de femme.
DOI: 10.1051/lait:1982617-62026
Structure des glycannes des immunoglobulines sIgA du lait de femme
Annick PIERCE-CRETEL and Geneviève SPIKLaboratoire de Chimie Biologique de l'Université des Sciences et Techniques de Lille / et Laboratoire associé au C.N.R.S. n° 217 - 59655 Villeneuve-d'Ascq
Abstract - Structure of the glycans ot secretory immunoglobulin IgA from human milk
Secretory IgA immunoglobulins (sIgA) of human milk play an important role in the protection of infant against intestinal infection. In order to determine the biological role of the sIgA carbohydrate moiety, particularly in the inhibition of bacterial adhesion on enterocytes in which are involved cell lectins (adhesins), we have undertaken the study of the primary structure of N-and O-glycosidically linked sIgA glycans. The results we obtained show an amazing heterogeneity of glycan structures, some of which are described.
Key words: Immunoglobulins / Glycans / Human milk.
Mots clés : Immunoglobulines A / Glycannes / Lait de femme.