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Issue Lait
Volume 73, Number 2, 1993
5th Meeting of the " Club des Bactéries Lactiques ".
Page(s) 207 - 213
DOI http://dx.doi.org/10.1051/lait:1993219

Lait 73 (1993) 207-213
DOI: 10.1051/lait:1993219

Les bactériocines contre Listeria : une nouvelle famille de protéines ?

Y. Hécharda, D. Renaulta, Y. Cenatiempoa, F. Letellierb, A. Maftahc, C. Jayatc, P. Bressolierc, M.H. Ratinaudc, R. Julienc, Y. Fleuryd and A. Delfourd

a  Laboratoire de biologie moléculaire, IBMIG, CNRS URA 1172, 86000 Poitiers
b  Laboratoire de microbiologie appliquée, lUT La Rochelle, 17000 La Rochelle
c  Institut de biotechnologie, 87000 Limoges
d  Laboratoire de biochimie des protéines, IBMIG, 86000 Poitiers, France

Abstract - Anti-Listeria bacteriocins: a new family of proteins ?
Anti-Listeria bacteriocins: a new family of proteins ? Lactic acid bacteria produce some bactericidal compounds. Among them, the bacteriocins are proteins possessing a narrow spectrum of inhibition. Some of these bacteriocins allow the inhibition of Listeria monocytogenes, a food-borne pathogen responsible for human listeriosis. These proteins seem to be closely related; they are produced by 2 genera of lactic acid bacteria: Pediococcus and Leuconostoc, they are small peptides with a molecular weight of 2 700 to 4 630 Da, and their encoding genes are plasmid-linked. Moreover, amino acid sequences are known for 3 of anti-Listeria bacteriocins, leucocin A, mesentericin Y105 and pediocin PA-1. These proteins have a strong sequence homology. We could thus put forward the hypothesis that anti-Listeria bacteriocin belong to the same family of proteins. We have attempted to sum up the information concerning anti-Listeria bacteriocins in differents fields, eg their mode of action.


Résumé - Les bactéries lactiques produisent différents composés bactéricides. Parmi ceux-ci les bactériocines sont des protéines possédant un spectre d'inhibition étroit. Certaines d'entre elles inhibent la croissance de Listeria monocytogenes, une bactérie pathogène pour l'homme responsable de la listériose. Toutes ces bactériocines présentent des caractéristiques similaires : production par Pediococcus ou Leuconostoc, faible poids moléculaire (de 2 700 à 4 630 Da), gène codant porté par un plasmide. De plus, la séquence en acides aminés est connue pour trois de ces bactériocines : la leucocine A, la mésentéricine Y105 et la pédiocine PA-1. Ces protéines montrent une homologie de séquence importante. Ce constat nous permet de faire l'hypothèse selon laquelle les bactériocines anti-Listeria appartiendraient à une même famille de protéines. Cet article fait le point sur la bibliographie concernant les bactériocines dirigées contre Listeria, dans différents domaines d'études et notamment sur leur mode d'action.


Key words: bacteriocin / Listeria monocytogenes / bacteriostatic / antibacterial activity / lactic acid bacteria

Mots clés : bactériocines / Listeria monocytogenes / bactériostatique / bactéricide / bactéries lactiques




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